Polymorphic HLA-C Receptors Balance the Functional Characteristics of KIR Haplotypes
نویسندگان
چکیده
منابع مشابه
Polymorphic HLA-C Receptors Balance the Functional Characteristics of KIR Haplotypes.
The human killer cell Ig-like receptor (KIR) locus comprises two groups of KIR haplotypes, termed A and B. These are present in all human populations but with different relative frequencies, suggesting they have different functional properties that underlie their balancing selection. We studied the genomic organization and functional properties of the alleles of the inhibitory and activating HL...
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The killer cell immunoglobulin-like receptors (KIR) are a recently discovered family of activating and inhibitory receptors which control natural killer (NK) cell function. KIR exist as a diverse family of receptors that have evolved rapidly by both gene duplication and recombination events. These findings were unexpected for a family of genes involved primarily in the innate immune response. H...
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ژورنال
عنوان ژورنال: The Journal of Immunology
سال: 2015
ISSN: 0022-1767,1550-6606
DOI: 10.4049/jimmunol.1501358